DESCRIPTION

APEX RECEPTOR YK11

30ml | 10mg per ml | Pure YK11 – Lab Verified

What Is YK11?

YK11, sometimes referred to as YK-11 SARM, is a synthetic androgen receptor modulator designed to interact selectively with androgen receptors. It was first developed to study the pathways involved in muscle and bone development.

In laboratory settings, YK-11 acts as a gene-specific agonist of the androgen receptor (AR) and influences multiple anabolic pathways. Studies on cell lines such as MDA-MB-453 and C2C12 myoblasts have shown that YK-11 can stimulate myogenic factors like MyoD and Myf5—key regulators of muscle cell differentiation.

Unlike injectable androgens, YK-11 is orally bioavailable, which allows researchers to evaluate its effects through oral administration in controlled environments.

YK 11 Benefits from Clinical Research

1. Muscle Growth and Follistatin Expression

One of YK-11’s defining features is its connection to follistatin, a naturally occurring protein that regulates muscle growth by inhibiting myostatin and related catabolic proteins (Activin A, Activin B).

Research suggests that YK-11 may stimulate follistatin expression both locally and systemically, which in turn can:

• Promote muscle cell differentiation
• Support amino acid and glucose uptake in skeletal muscle
• Reduce myostatin-related muscle breakdown

This mechanism distinguishes YK-11 from traditional anabolic agents and provides a promising avenue for continued study into muscle preservation and recovery.

2. Bone Cell Research and Growth Potential

In vitro testing on MC3T3-E1 osteoblast cells showed that YK-11, alone or in combination with DHT, can accelerate cell proliferation and mineralization. The treatment also increased the expression of bone differentiation markers such as osteocalcin and osteoprotegerin.

These effects appear to be mediated through the androgen receptor (AR) and Akt phosphorylation pathway, which are important in bone tissue regulation and recovery.

3. Muscle Wasting and Cytokine Response

Animal studies examining sepsis-induced muscle loss have reported that YK-11 treatment correlated with:

• Improved muscle tissue protection
• Reduced cytokine-related inflammation
• Lower mortality rates in experimental models

These outcomes were attributed to myostatin suppression and increased follistatin gene expression, making YK-11 a continuing focus in the field of muscle-wasting research.

Potential YK11 Side Effects

Published data on YK-11 side effects remains limited. However, anecdotal reports and structural similarities to other androgenic compounds suggest the need for caution in laboratory environments. Possible observations include:

• Temporary joint discomfort
• Skin and hair changes
• Fluctuations in lipid and hormone markers

Because YK-11 acts on the androgen receptor, similar considerations apply as with other AR-modulating compounds. Researchers should handle this material under appropriate conditions and within approved safety protocols.

Browse YK11 Collection

CONCENTRATION

30ml - 10mg per ml

SHIPPING

UK

Royal Mail Tracked 24 - £4.49

Royal Mail Tracked 48 - £3.49

FREE SHIPPING OVER £50

EUROPE

Royal Mail International Tracked £8.00

FREE SHIPPING OVER £200

DISCLAIMER

This material is sold for use in laboratory research only. Terms of sale apply. Not for human consumption, nor for medical, veterinary or household use.

FAQs

What is the recommended dosage for YK-11?

The typical dosage for YK-11 ranges from 5 to 15 mg per day, taken orally. A cycle usually lasts between 4 to 8 weeks. It's advised to start with a lower dose to assess tolerance.

Does YK11 suppress testosterone?

Like other SARMs, lab tested YK11 has a dose dependent reductive effect on natural testosterone levels in males.

Where can I buy YK-11?

YK-11 is available through various online retailers as a research chemical. It's important to purchase from reputable sources to ensure product purity and quality. Always check local laws and regulations before purchasing.

For more information about commonly researched compounds like YK-11, check out our SARMs FAQ blog post

SCIENTIFIC REFERENCES

1. Dual Mechanism: Myostatin Inhibition and Androgen Receptor Agonism

Summary: YK-11 functions as a partial agonist of the androgen receptor and inhibits myostatin by increasing follistatin expression, potentially leading to enhanced muscle growth and strength.

Source: ChemicalBook

2. Preclinical Evidence of Muscle Hypertrophy

Summary: Animal studies have suggested that YK-11 may promote muscle hypertrophy by inhibiting myostatin, leading to increased muscle mass and strength.

Source: PubMed Study

3. Potential Neurochemical Effects

Summary: Research indicates that YK-11 may influence neurochemical mechanisms in the hippocampus, potentially affecting memory consolidation and inflammatory cytokine levels.

Source: PubMed Study

4. Oxidative Stress and Mitochondrial Dysfunction

Summary: Studies have shown that YK-11 administration may lead to increased oxidative stress and mitochondrial dysfunction in the hippocampus, suggesting potential neurological risks.

Source: ScienceDirect Article

5. Reported Side Effects

Summary: Anecdotal reports suggest that YK-11 may cause side effects such as hair loss, acne, increased aggression, and potential liver toxicity, particularly at higher doses.

Source: ChemicalBook Side Effects