APEX RECEPTOR MK 677 (IBUTAMOREN)
APEX RECEPTOR MK 677 (IBUTAMOREN)
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DESCRIPTION
APEX RECEPTOR MK677
SARM MK677, also known as Ibutamoren, Oratrope, or Nutrobal (molecular weight 528.662), is a Ghrelin agonist that acts on the pituitary gland as a human growth hormone secretagogue and is sometimes classified along with selective androgen receptor modulators (SARMs).
It differs from Ghrelin itself in that it is not a peptide but rather a spiropiperidine. Since it can cross the blood-brain barrier, MK-677 functions as a neuropeptide in the central nervous system.
MK677 is a highly sought-after compound with a range of potential applications. As a growth hormone secretagogue, it is known for its ability to support the natural production of growth hormone, which plays a key role in various physiological processes.
Research suggests that MK677 may influence metabolism, body composition, and overall well-being. It has been associated with increased lean mass, enhanced recovery, and support for skin, hair, and nail health. Additionally, it has been studied for its potential to improve sleep patterns and support general vitality.
Clinical investigations have highlighted its effectiveness in stimulating growth hormone and IGF-1 levels, potentially providing benefits similar to synthetic alternatives but without the drawbacks often associated with injectables. MK677’s stability as a compound and its affordability make it an appealing option for those exploring innovative approaches in this area.
MK-677 Benefits from Clinical Research
MK 677 has displayed multiple effects in vivo, including:
- Increase in GH levels
- Increase in muscle mass and lean body mass
- Reduced body fat
- Increase in bone density
- Faster muscle growth
- Improved immune function
- Improved REM sleep
- Increased appetite
- Reversal of growth hormone deficiency
- Alleviation of pathology related to beta amyloid
Potential MK677 Side Effects
However, it must be emphasised that MK 677 has not been approved by the Food and Drug Administration (FDA) for human consumption and efficacy. The severity of documented side effects like water retention, angiogenesis, and changes in blood pressure and blood sugar are still being determined. Potential drug interactions are also unknown at this time so caution is critical with this compound.
Since it has a very long half life, there is a some concern that sustained administration of MK-677 can overstimulate or desensitise the ghrelin receptor in the human brain. Perhaps the most immediately noticeable side effect of Ibutamoren at this time is a significant increase in appetite and hunger.
CONCENTRATION
30ml - 25mg per ml
SHIPPING
UK
Royal Mail Tracked 24 (1 Day Delivery) - £4.49
Royal Mail Tracked 48 (2-3 Days Delivery - £3.49
FREE SHIPPING OVER £50
EUROPE
Royal Mail International Tracked £8.00
FREE SHIPPING OVER £200
DISCLAIMER
This material is sold for use in laboratory research only. Terms of sale apply. Not for human consumption, nor for medical, veterinary or household use.
FAQs
There is presently no evidence that MK677 compromises the body’s natural release of GH long term. More information may be available in the future.
Can MK 677 trigger gynecomastia?
A two-year human study on MK677 found that subjects experienced a significant decrease in the risk of developing gynecomastia when compared to the administration of injectable Growth Hormone.
Does MK 677 suppress testosterone?
MK-677 does not act on the feedback loop for testosterone in the body and is not expected to suppress natural testosterone levels.
Studies have demonstrated the ability of MK 677 (aka Nutrobal) to raise endogenous levels of HGH and IGF-1.
For more information about commonly researched compounds like MK-677, check out our SARMs FAQ blog post
SCIENTIFIC REFERENCES
1. MK-677 and Lean Body Mass in Older Adults
Summary: A 12-month clinical trial in older adults found that daily MK-677 administration increased growth hormone (GH) and insulin-like growth factor 1 (IGF-1) to levels similar to those seen in younger adults. This was associated with increases in fat-free mass and lean body composition.
Source: PMC Article
2. Effects on Muscle Preservation During Caloric Restriction
Summary: Research indicates MK-677 may help maintain muscle mass in calorie-restricted conditions. Studies observed improvements in nitrogen balance and preservation of lean tissue in controlled experimental settings.
Source: PubMed Study
3. Potential Improvements in Bone and Muscle Health
Summary: In various studies, MK-677 has been investigated for its effects on bone density markers and lean mass. Results suggest potential anabolic-like effects on muscle tissue in laboratory and clinical research contexts.
Source: PubMed Study
4. Reported Side Effects in Research
Summary: Clinical studies reported mild, transient side effects such as increased appetite, temporary swelling in extremities, and mild muscle discomfort. Blood glucose levels and insulin sensitivity were sometimes affected in study participants.
Source: Healthy Male Australia
5. IGF-1 and Growth Hormone Stimulation
Summary: MK-677 is known as a growth hormone secretagogue in research settings, meaning it stimulates GH and IGF-1 release. This hormonal response is associated with anabolic effects on muscle tissue and lean body composition in study environments.
Source: PMC Article
