MK-677 vs RAD-140 Research Comparison
Introduction
When it comes to SARMs and related research compounds, two names that often stand out are MK-677 (Ibutamoren) and RAD-140 (Testolone). While they’re sometimes grouped together, these two compounds are very different in how they work, what researchers study them for, and their potential applications.
In this article, we’ll break down the key differences between MK-677 and RAD-140, highlight findings from published research, and show how they’re typically referenced in studies.
⚠️ Disclaimer: SARMs are sold strictly for research purposes only. They are not approved for human consumption. This article is for informational and educational purposes only.
What Is MK 677 (Ibutamoren)?
MK-677 is not technically a SARM but a growth hormone secretagogue. Research has shown that it stimulates the release of growth hormone (GH) and insulin-like growth factor 1 (IGF-1).
Research Highlights
- Hormone Levels: Studies demonstrate significant increases in GH and IGF-1 after MK-677 administration.
- Muscle & Recovery: Because GH and IGF-1 play roles in muscle growth and recovery, MK-677 has been investigated for its potential to support lean mass.
- Other Areas of Study: Some studies suggest benefits in sleep quality and bone density support.
Source: PubMed – MK-677 Growth Hormone Study
Shop: See our full SARM MK 677 collection.
What Is RAD 140 (Testolone)?
RAD-140, on the other hand, is a selective androgen receptor modulator (SARM). It binds to androgen receptors in muscle and bone tissue, stimulating anabolic activity.
Research Highlights
- Muscle Development: Preclinical studies show RAD-140 increases lean muscle mass and may mimic some anabolic effects of testosterone.
- Bone Research: Investigated for its potential in bone density preservation.
- Safety Data: Some case reports suggest possible liver and cardiovascular risks, though more studies are needed.
Source: ACS Medicinal Chemistry Letters – RAD-140
Shop: See our full SARM RAD 140 collection.
Key Differences: MK 677 vs RAD 140
| Feature | MK-677 (Ibutamoren) | RAD-140 (Testolone) |
|---|---|---|
| Type | GH secretagogue | SARM |
| Primary Mechanism | Stimulates GH & IGF-1 release | Activates androgen receptors |
| Research Focus | Muscle size, recovery, sleep, bone density | Muscle growth, strength, bone health |
| Human Studies | Yes, limited | Mostly preclinical, some case reports |
| Approval Status | Not approved for human use | Not approved for human use |
Which Is More Popular in Research?
- MK-677 is often referenced in studies on hormone levels, aging, and muscle recovery.
- RAD-140 is frequently highlighted in anabolic and performance-related research.
Both compounds continue to attract scientific attention, though their mechanisms and focus areas are quite distinct.
Conclusion
When comparing MK-677 vs RAD-140, it’s clear they operate very differently. MK-677 influences hormone pathways by increasing GH and IGF-1, while RAD-140 directly stimulates androgen receptors in muscle and bone tissue.
For researchers, choosing between them depends on the specific focus of the study — whether it’s hormone-related effects, muscle development, recovery, or bone health.
👉 For more details, shop our full SARMs collection.
